Karen I. Lange, PhD
Research Fellow
I am a geneticist who is passionate about harnessing the power of genome engineering in model organisms to diagnose and identify potential treatments for rare genetic disorders. My research focuses on using CRISPR genome editing in Caenorhabditis elegans to generate patient-specific disease models. These models can then be used to determine how the variants affect gene function.
I currently work in the Conway Institute at University College Dublin in Ireland.
Relevant Publications
Lange, K. I., Best S., Tsiropoulou S., Berry I., Johnson C. A., & Blacque, O. E. (2022). Interpreting ciliopathy-associated missense variants of uncertain significance (VUS) in Caenorhabditis elegans. Human Molecular Genetics. [Preprint]
Lange, K. I., Tsiropoulou, S., Kucharska, K., & Blacque, O. E. (2021). Interpreting the pathogenicity of Joubert Syndrome missense variants in Caenorhabditis elegans. Disease Models & Mechanisms. 14(1). [Preprint]
Full publication list available on ORCiD or Google Scholar.